Gray Hair and Copper Metabolism: Mechanistic Links, Biomarkers, and Evidence-Based Clinical Considerations
“Gray hair” (premature canities when occurring before ~30–50 years depending on sex and ethnicity) reflects complex changes in melanocyte biology, oxidative stress, and pigment synthesis. A growing body of translational research explores whether trace-metal dysregulation—particularly copper—can influence melanogenesis. Copper is an essential cofactor for multiple enzymes that support melanocyte function and melanogenesis, including tyrosinase (a… Read More »