Chronic Myeloid Leukaemia (CML): Pathophysiology, diagnosis, treatment including stem-cell transplantation
Chronic myeloid leukaemia (CML) is a clonal myeloproliferative neoplasm characterized by sustained proliferation of myeloid lineages in the bone marrow and peripheral blood. The hallmark of most cases is the BCR-ABL1 fusion gene produced by the Philadelphia chromosome (t(9;22)(q34;q11.2)). This fusion encodes a constitutively active tyrosine kinase that drives signaling through pathways such as RAS/MAPK,… Read More »