MC1R Gene Variants and Red Hair Biology: Pigment Pathways, Eumelanin vs Pheomelanin, and Health Implications
MC1R (melanocortin 1 receptor) gene variants are central to the biology of human red hair and the related “reddish” pigment phenotype. MC1R is expressed primarily in melanocytes and regulates the synthesis of melanin, the pigment responsible for skin, hair, and some ocular coloration. In canonical signaling, α-MSH (alpha-melanocyte–stimulating hormone) binds MC1R, triggering a cAMP-mediated pathway… Read More »