Cell-free DNA Fragmentomics: Emerging Genomic Signal Processing for Early Cancer Detection and Monitoring
Cell-free DNA (cfDNA) fragmentomics refers to the quantitative and qualitative analysis of DNA fragments circulating in blood, particularly the patterns of fragment sizes, ends, and genomic coverage that reflect underlying tissue-specific biology. Unlike conventional liquid biopsy approaches that focus mainly on variant allele frequencies (e.g., single-nucleotide variants), fragmentomics extracts “how the DNA is cut and… Read More »