Aging Bone Microenvironment and Tissue Repair: How Clearance of Senescent Signals Improves Bone Defect Healing
The integrity of bone repair depends not only on osteogenic cells but also on the surrounding “aging microenvironment,” a biological niche that increasingly favors dysfunction as organisms age. In the context of bone defects—such as fractures that fail to heal, critical-size defects, and large surgical bone gaps—remodeling requires a coordinated sequence of inflammation, angiogenesis, recruitment… Read More »