Chronic Myeloid Leukemia (CML): Pathogenesis, Diagnosis, Tyrosine Kinase Inhibitors, and Stem Cell Transplant
Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm driven by a defining genetic lesion: the Philadelphia chromosome. This results from a reciprocal translocation between chromosomes 9 and 22, producing the BCR-ABL1 fusion gene. The BCR-ABL1 tyrosine kinase is constitutively active, triggering downstream signaling pathways that promote increased proliferation, impaired apoptosis, and altered differentiation of… Read More »