By Trend News Line 2024-06-02 22:08:00.
Berlin Researchers Develop New Method to Improve Influenza Vaccine Effectiveness
In a groundbreaking discovery, researchers in Berlin, Germany, have developed a new way of classifying host immunity in individuals to enhance the effectiveness of influenza vaccines. This breakthrough could potentially revolutionize how vaccines are administered, leading to better protection against influenza and reducing the burden on healthcare systems.
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Identifying Individuals with Low Vaccine Protection
The study, presented at the annual conference of the European Society of Human Genetics, involved taking blood samples from 286 healthy donors aged 18-81 over four influenza seasons. By analyzing pre- and post-vaccination antibody levels using multiomics technology, the researchers were able to identify proteins and metabolites that could predict individuals with low levels of protection even after vaccination.
Challenges in Vaccine Response
One of the key challenges in influenza vaccination is the variability in vaccine response among individuals. The annual updates to the influenza vaccine mean that pre-vaccination antibody levels can differ based on previous infections or vaccination history. Current methods of assessing vaccine response may not provide accurate information on an individual’s immune response, leading to suboptimal protection.
Personalized Vaccine Administration
The researchers hope that the biomarkers identified in their study can pave the way for personalized influenza vaccine administration. This could involve tailored vaccine regimes such as higher dose vaccines, repeated vaccinations, or vaccines with adjuvants to enhance the immune response. By developing individualized strategies for vaccine administration, the researchers aim to improve protection against influenza and reduce the cost of vaccine response screening.
Future Prospects and Market Potential
The potential applications of this research are vast. The researchers are currently testing a molecule that could serve as both a predictive biomarker and a modulator of influenza vaccine response. They also plan to explore the development of a diagnostic test based on their findings. The ultimate goal is to create personalized influenza vaccination strategies based on the biomarkers identified in the study.
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Implications for Public Health
Professor Alexandre Reymond, chair of the conference, emphasized the importance of personalized health in identifying individuals at risk and treating them specifically. By targeting those who may not respond well to standard vaccine schedules, personalized vaccination strategies could benefit both individuals and the healthcare system as a whole, ultimately reducing the burden of influenza-related illness.
This groundbreaking research has the potential to revolutionize how influenza vaccines are administered, leading to better protection and improved public health outcomes. The development of personalized vaccination strategies based on individual immune responses could mark a significant step forward in the fight against influenza..
personalised flu vaccination schedule
new biomarkers enabled personalized flu vaccination.
