By Trend News Line 2024-04-09 14:32:00.
Researchers Uncover Link Between Heart Disease and Cancer
In a groundbreaking study conducted by researchers at Tel Aviv University (TAU) and the Leviev Cardiothoracic and Vascular Center at the Sheba Medical Center, a significant discovery has been made regarding the relationship between heart disease and cancer. The team of experts identified a mechanism that increases the risk of cancer development among patients with heart disease, shedding light on a previously unknown connection.
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Extracellular Vesicles: The Culprits Behind Cancer Growth
The research focused on small extracellular bubbles, known as vesicles (sEVs), that are secreted from a diseased heart as part of its healing process. These vesicles, which contain various factors related to inflammation, growth, and immune system modulation, were found to promote the growth of cancer cells when released into the bloodstream. This discovery highlights the complex interplay between heart disease and cancer and underscores the importance of considering the risk of cancer in heart disease treatment protocols.
Insights from the Study
Lead researcher Prof. Jonathan Leor and his team discovered that sEVs released by a damaged heart can directly contribute to the growth of certain tumors and create an environment conducive to cancer development. By inhibiting the production of these vesicles in animal models, the researchers were able to reduce the risk of cancer, albeit with undesirable side effects. However, a different approach involving the treatment of the heart with spironolactone, a drug used to treat heart failure, showed promising results in reducing sEV production and slowing down tumor growth.
Implications for Patient Care
The findings of this study have significant implications for the treatment of patients with heart disease. By understanding the role of sEVs in promoting cancer growth, clinicians may be able to tailor treatment strategies to reduce the risk of cancer in these patients. Additionally, the identification of biomarkers that indicate an increased risk of cancer among heart patients could lead to more personalized and effective care.
A Call for Further Research
While the study has provided valuable insights into the link between heart disease and cancer, lead researcher Tal Caller emphasizes the need for more research to fully understand this complex relationship. The team’s work has laid the foundation for future studies that aim to unravel the intricate mechanisms by which the heart contributes to cancer development.
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Hope for the Future
Moshe Bar-Haim, CEO of the Israel Cancer Association, commended the research for its potential impact on patient care and the global fight against cancer. The collaboration between researchers and medical professionals in Israel has the potential to revolutionize the way heart disease and cancer are treated worldwide, paving the way for more targeted and effective therapies.
In conclusion, the groundbreaking research conducted by the team at Tel Aviv University and the Sheba Medical Center has provided valuable insights into the connection between heart disease and cancer. By uncovering the role of sEVs in promoting cancer growth, the researchers have opened up new possibilities for improving patient care and advancing our understanding of these complex diseases..
– Link Between Heart Disease and Cancer Development
– Heart Disease and Cancer Development Connection.
