By Trend News Line 2024-04-02 10:03:00.
**Groundbreaking Research Reveals Insights into Lumpy Skin Disease Virus Outbreak**
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**Unveiling the Origins of the Lumpy Skin Disease Virus**
A recent study conducted by a team of Indian scientists has shed light on the evolution and origins of the Lumpy Skin Disease Virus (LSDV) strains that have been fueling a devastating outbreak in India. The outbreak, which began in May 2022, has had a severe impact on the country’s agricultural sector, leading to significant economic losses.
**The Calamity of the LSDV Outbreak**
According to the Indian Institute of Science (IISc), approximately 1 lakh cattle heads have been lost to the outbreak, making it a national emergency. Professor Utpal Tatu, a member of the research team, described the situation as a “calamity” and emphasized the urgent need to address the crisis.
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**Advanced Genomic Analysis Reveals Distinct LSDV Variants**
The team of researchers conducted advanced whole-genome sequencing of 22 samples collected from infected cattle in various states, including Karnataka, Gujarat, Maharashtra, and Rajasthan. Their analysis uncovered two distinct LSDV variants, one with a low number of genetic variations and another with a high number of variations.
**Possible Introduction of Foreign Strain**
Of particular concern was the discovery that the highly varied LSDV strain bore similarities to strains from an outbreak in Russia in 2015, suggesting a possible introduction of a foreign strain into India. The researchers identified over 1,800 genetic variations, including deletions, insertions, and single-letter changes in DNA, many of which were located in viral genes critical for host cell binding, immune evasion, and efficient replication.
**Impact of Genetic Variations on Disease Severity**
The study also found that cattle in areas where highly diverse LSDV strains were present exhibited more severe symptoms, indicating that genetic variations could contribute to increased virulence. This information will be crucial in the development of vaccines targeted at specific molecular hotspots and genetic variations.
**Collaborative Efforts in One Health Approach**
The research represents a prime example of the One Health approach, where multidisciplinary teams, including molecular biologists, computational experts, and veterinary doctors, work together to address national issues. Collaboration between veterinary experts and scientific institutions played a crucial role in tracing the spread of LSDV variants across the country.
**Looking Towards Vaccine Development**
Professor Tatu highlighted the importance of the genomic data in informing vaccine development efforts. By understanding the genetic makeup of the virus and its impact on disease severity, researchers can tailor vaccines to target specific variations and reduce the spread of LSDV.
**Invaluable Lessons from Veterinary Experts**
The researchers emphasised the invaluable contributions of veterinary doctors in understanding the disease and its impact on livestock. Their field knowledge and insights were instrumental in guiding the research and identifying strategies to combat the outbreak.
**Conclusion**
The groundbreaking research conducted by Indian scientists has provided critical insights into the evolution and origins of the LSDV strains driving the outbreak in India. By leveraging advanced genomic analysis and collaborative efforts, researchers are paving the way for targeted vaccine development and effective control measures to combat the devastating effects of the disease on the country’s agricultural sector..
1. Indian scientists unravel genetic secrets behind lumpy skin disease outbreak
2. Indian scientists genetic secrets lumpy skin disease outbreak.
