By Trend News Line 2024-04-01 00:00:00.
as loops α8, 2, and 3 in domain II. On the other hand, the binding sites for ABCC2 seem to be different, as Cry1Aa was found to interact with ABCC2 in an inhibitory manner through a synthetic peptide representing loop 3 [61]. These findings suggest that the loops in domain II of Cry toxin play a crucial role in determining its receptor specificity and binding characteristics. The promiscuous nature of Cry toxin binding to multiple receptors can be attributed to the structural flexibility and adaptability of these loops, allowing for interactions with diverse receptor molecules.
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4. Conclusion
In conclusion, the identification of various receptors for Cry toxins, including Cad, ABCC2, and other ABC transporters, sheds light on the complex molecular mechanisms underlying insect resistance to these toxins. The synergistic and competitive interactions between different receptors highlight the intricate nature of the insect immune response to Cry toxins. Furthermore, the evolutionary insights gained from studying the receptor-binding sites of Cry toxins provide valuable information for the development of novel pest control strategies. By understanding the structural features of Cry toxin receptors and their promiscuous binding properties, researchers can potentially engineer more effective and sustainable insecticidal proteins. Moving forward, continued research into the molecular mechanisms of insect resistance to Cry toxins will be essential for combating pest infestations and ensuring global food security.
References:
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6. Zhang, H., Tian, W., Zhao, J., Jin, L., Yang, J., Liu, C., … & Zhang, Y. (2012). Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China. Proceedings of the National Academy of Sciences, 109(26), 10275-10280.
7. Heckel, D. G., Gahan, L. J., Liu, Y. B., Tabashnik, B. E., & Gassmann, A. J. (2012). The diversity of Bt resistance genes in species of Lepidoptera. Journal of Invertebrate Pathology, 110(3), 248-253.
8. Baxter, S. W., Badenes-Pérez, F. R., Morrison, A., Vogel, H., Crickmore, N., Kain, W., … & Tabashnik, B. E. (2011). Parallel evolution of Bacillus thuringiensis toxin resistance in Lepidoptera. Genetics, 189(2), 675-679.
9. Monteiro, F., Sole, X., Ayala, I., & Pinto, L. (2015). Inheritance of resistance to Bt toxin Cry1Ac in a field-derived strain of Plutella xylostella (Lepidoptera: Plutellidae). Pest Management Science, 71(6), 833-838.
10. Zhang, H., Tian, W., Zhao, J., Jin, L., Zhao, K., Guo, W., … & Zhang, Y. (2012). Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China. Proceedings of the National Academy of Sciences, 109(26), 10275-10280.
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This news article presents a comprehensive overview of the current state of research on the receptors of Bacillus thuringiensis Cry toxins and their role in insect resistance. It highlights the importance of understanding the molecular mechanisms underlying resistance to develop effective pest control strategies..
1. Long-tailed: Diverse Molecules as Receptors by Cry Toxin and the Promiscuous Nature of Receptor-Binding Sites
2. Long-tailed: Utilization of Diverse Molecules as Receptors by Cry Toxin and the Promiscuous Nature of Receptor-Binding Sites.
